Bought Rocksmith 2014 for Mac/PC a couple of weeks ago. It's been working fine but every once in a while would glitch out and start making random string/buzz/static sounds, even with the guitar unplugged. I would restart the program or computer and it was fine. Now, nothing I do resolves the issue.
I have the latest Macbook Air and have tested the issue in both Mavericks(10.9) and on Windows 7 x64(Bootcamp)
Both exhibit the same issue. I have tried plugging directly into a USB port or a USB hub on a monitor I use which has been working fine.
Note this issue occurs even when the guitar itself is unplugged. As soon as the cable is plugged in, the fun begins.
I can play notes on the guitar and those are registered to but it totally ruins any actual playing of songs.
Let me know if there's anything further I can provide.