Sorry I can't help you with getting the tone in RS, but I've gotta back you up on LOVING Clutch. Those guys are awesome and probably one of my favorite jam bands out there. Such an under appreciated band. How can you not like a band with an album titled "Pure Rock Fury" If you have the opportunity, see 'em live!
One of these days, I'll be working out some Clutch tunes too , so I hope you figure out the tone.
The game needs a Clutch pack! Seen them live 3 times, one of my favorite bands ever. As for finding his tone, I'll have to try. He uses wah a lot not sure if on Profits of Doom. Probably start with finding the right distortion and maybe some eq