I prefer songs in drop D.
Either way is fine with me, I just retune and go.
I avoid songs in drop D.
I'm also one of the guys who avoid drop D,and also like some mainly because of the fact that my guitar has a "floating bridge".
But getting a secondary fixed bridge guitar,that will stay at drop D or any other lower tunings that may come in the future will be easy and wont need to be like my primary guitar..
Top-of-the-line expensive.. xD
I highly recommend the TREMOL-NO. You can basically turn your tremolo from full float to a fixed bridge hand-turning a few screws. Most of the time it is an easy install, but a few bridges will need more adjustments. It's about $50 on musicians friend. It's worth it for other tunings. It also adds sustain and keeps other strings in tune during bends. Definitely cheaper than another guitar.
Now if Rocksmith wanted to start using Open G, or D tunings I might be a little put off. But never know I have been thinking about trying to play Slide guitar after they released Jessica.
I love Drop D! I can't imagine ever trying to avoid it, but hey, if we were all the same there'd only be one song, right?
That being said, I'd be REALLY happy if they put out Eb as a tuning option, and/or Drop Db...
Even though some of my favourite songs in the game are in drop D (Unnatural Selection, Gold on the Ceilling), I acutally avoid tuning my guitar in drop D. It's because it's a BC Rich Warlock and it has a Floyd Rose. It's really hard to get the good tuning sometimes. I'd rather let my guitar tuned as it is and don't waste to much time tuning it just to do like one or two performances.
Why would I? It's not that difficult to retune a guitar...takes all of a minute or two.