I see on here a lot of speculation over where the next installment of assassin's creed will take place and I guess everyone wants to see their hometown in a video game, so here's my bid:
In 1920 the Legislative building of Manitoba was built to replace the old piece of crap that was there. The principal architect Frank Worthington Simon (1862-1933) was greatly inspired by free-masonry but it was not until a local man, Frank Albo (then studying in Europe about architecture) that the more subtle nuances of the building came to light: it is by rites the worlds largest masonic temple (no jokes here) and the original building was built to the exact specifications of the architect (Simon) who died poor having donated a large portion of his fee to have the building completed.
Secondly, in the more current attitude of the times Winnipeg, Manitoba, Canada is in the middle of bald-*** prairie right at the juncture of the Red and Assiniboine Rivers (and was thus a huge centre for aboriginal trade in the past). Due to seasonal flooding, the city is surrounded by a massive **** as well as a perimeter highway... cutting off the city from outward fire or chemical attack... and at dead center of it all? One of the sites that grows the vaccine for the smallpox virus.
Not to mention that Winnipeg itself is the center-most capital of the north american continent.
As for historic importance one of the original leaders of winnipeg was Louis Riel, a metis leader who started a rebellion once successfully and was killed the second time around. The Winnipeg general strike which took place as the leg. bldg was being built in 1919 saw 30 000 workers in the streets.
I don't know how this might be incorporated in the game... but i thought i may as well mention it to see if it could turn some heads.... because there aren't many Manitoban samuraii, assassins or pirates.... unless Louis Riel had some kind of elite metis terrorists.