This thread is to provide you with a single location for all patch Updates, Info, and Support for the PC version of Far Cry 2.
All PC patches can be downloaded here.
Far Cry 2 PC Patch Downloads
The first time you run the game, the autopatcher checks for updates before the activation request kicks in, provided the autopatch updates ok, the DRM is removed and you then no longer are asked to activate the game.
You should only need to manually patch if the autopatch fails.