Originally posted by pzrzao:
After playing through the game 8 times, each without a single problem I'm wondering why I've been so lucky. This is pure conjecture, but I've been a programmer (ages ago) and this is a plausible explanation. In each interaction with someone (buddy, APR, UFLL officials, etc) I let them competely finish what they are saying before I move on. Also, when returning from a buddy quest to report to the buddy at Mike's, I always wait the few seconds to see the Mission completed message, and then the Reputation increased message before I move on. It is possible that if the person you are interacting with does not complete their programmed routine, the next mission you attempt will not work properly, thus introducing a flaw into your current saved game that you will not recover from. This also would explain why an earlier save did not work.
As I mentioned, this is purely guesswork, but it might explain some of the "glitches" that some people experience while others do not.