I've played through to The Spider Cavern or whatever its called. I went through the web area and came to the long shaft going up, killed a few spiders, and then crash. I reloaded, did it again, crash. It seems to be crashing when a certain sound effect is playing, because it doesnt matter where I stand, or what I do, it just crashes at the same time every time. I've tried changing settings, but it does nothing.

Is there a fix for this?

Download and install the patches 1.01 and 1.02.
Also see this thread