I can't wait to see how the game story will fit in with the previous seasons of Lost.
I've also heard that in the season 3 DVD set if you freeze frame certain scenes there are links to the game.

I've watched the complete 3rd season of LOST on Blu-ray disks and have not seen even the slightest indication of any sort of hint to the game. However, Amazon.com has an interview up on their site linked to from the LOST: Via Domus page, were one of the cheif developers had said there might be some sort of feature of the games main character in the show. So let's keep our eyes open for him.

The main character looks like one of the background characters Ive seen in older episodes. Or maybe its just me

nonsense! main char looks like the guy from Far Cry
[it's one of UBI's other titles and this game's characters look a little too much like that game's]
I guess I'll have to stop by Bestbuy and see if it's worth picking up. I want the PS3 version but will probably wait until it drops to $29 to match PC version's price.

I think it was more to do with maps/charts in the stations featured in the show. I think the character in the game will make use of them. Until I get the game I can't be certain.