Hello,
I have installed Myst 5 on Windows Vista and it seems that the game can't save a resolution higher than 1024 x 768. You can change the resolution in the game, but if you play the game for example in 1280 x 1024 all graphical settings are deleted next time you start the game. Can anybody help me?

Welcome to the Forums!

Can you successfully change screen resolution back to 1280x1024 when you restart a saved game, or does it stay 1024x768?

I can change it back after restarting the game, but I have to change all graphical settings everytime I want to play the game.

I even tried to run the game as administrator and in compatibility mode (Windows XP SP2)

Try this fix:
http://cho.cyan.com/patches/Myst5InitFiles.zip

The fix doesn't solve the problem but thanks for the link.